The proteins of lead-induced intranuclear inclusion bodies.

Intranuclear Inclusion Bodies I N Carcinoma of the Thyroid Gland

Many authors have written about intranuclear inclusion bodies ; their presence has usually been linked with known virus infection, and their association with tumors has been less frequently reported. Intranuclear inclusions have been described, however, by Luck6 (1) in adenocarcinoma of the frog’s kidney. Russell ( 2 ) , and Wolf and Orton (3 ) have reported inclusion bodies in nuclei of the ce...

Lead-Induced Inclusion Bodies: Composition and Probable Role in Lead Metabolism

Lead-induced inclusion bodies in renal tubular cells of rats have been studied in vitro after isolation by differential centrifugation. The inclusion bodies are insoluble in physiological media but may be dissolved in denaturants like 6M urea and sodium deoxycholate. They contain about 40-50 mug of lead/mg protein, but only about 10% of this is tightly bound. They also contain calcium, iron, zi...

Idiopathic intranuclear inclusion bodies in the renal tubular epithelia of Japanese quail (Coturnix coturnix japonica).

We report idiopathic intranuclear inclusion bodies in the renal tubular epithelia of two cases of among the 960 Japanese quail (Coturnix coturnix japonica) in the course of the acute oral toxicity and dietary toxicity test. Basophilic inclusion bodies were seen only in the nuclei of renal tubular epithelia. We could not classify our case into any adenovirus infection by clinical signs and lesio...

Studies on Infectious Canine Hepatitis Iii. : Studies on the Intranuclear Inclusion Bodies

[In vitro renaturation of proteins from inclusion bodies].

Recombinant proteins and enzymes are commonly used in many areas of our life, such as diagnostics, industry and medicine, due to heterologous synthesis in prokaryotic expression systems. However, a high expression level of foreign protein in bacteria cells results in formation of inactive and insoluble aggregates--inclusion bodies. Reactivation of aggregated proteins is a complex and time-consu...